Pediatric Kaposi's sarcoma associated with immune reconstitution inflammatory syndrome

L Silva, L Azurara, AF Monteiro… - Pediatric …, 2020 - Wiley Online Library
L Silva, L Azurara, AF Monteiro, A Miroux-Catarino, C Amaro, I Viana
Pediatric Dermatology, 2020Wiley Online Library
Immune reconstitution inflammatory syndrome (IRIS) represents paradoxical immune‐
mediated inflammation in response to an infecting pathogen, occurring after initiation of
antiretroviral therapy (ART), concomitantly with immune system recovery. It has also been
described in Kaposi's sarcoma (KS). We report a case of a 9‐year‐old Guinean girl, who
developed Kaposi's sarcoma, following introduction of ART. KS associated with immune
reconstitution inflammatory syndrome is rare, especially in children, but with the increased …
Abstract
Immune reconstitution inflammatory syndrome (IRIS) represents paradoxical immune‐mediated inflammation in response to an infecting pathogen, occurring after initiation of antiretroviral therapy (ART), concomitantly with immune system recovery. It has also been described in Kaposi's sarcoma (KS). We report a case of a 9‐year‐old Guinean girl, who developed Kaposi's sarcoma, following introduction of ART. KS associated with immune reconstitution inflammatory syndrome is rare, especially in children, but with the increased use of ART is becoming more prevalent.
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